Oldřich Lapčík

ANABOLICS – MUSCLES IN A PILL?

Oldrich Lapcik

Department of Chemistry of Natural Compounds, Faculty of Food and Biochemical Technology, University of Chemistry and Technology Prague, Technicka 5, 16628 Praha 6, Czech Republic
lapciko@vscht.cz

The relationship between masculinity and musculature has been revealed since ancient times. Testicular extracts with strengthening effects are mentioned in the literature from ancient Rome (Gaius Plinius Secundus, 23-79) to almost the present (Ch-E. Brown-Séquard, 1817-1894).

The discovery of steroid hormones and a synthetic approach to them in the 1930s opened up new possibilities (Butenadt, Ruzicka). Orally active testosterone analogues (17α-methyltestosterone, Ruzicka 1935) have been included in the repertoire of medicinal steroids since 1935. Shortly after confirmation of their therapeutic potential (replacement of endocrine function of the testicles, reconvalescence acceleration after injuries) anabolic steroids began to gain a ground in strength sports.

Abuse of high doses has led to numerous side effects, including the deaths of athletes. Anabolics have been on the IOC Prohibited Substances List since 1975, and the World Anti-Doping Association (WADA) Prohibited Substances and Methods List is updated annually (https://www.wada-ama.org/sites/default/files/2022-01/2022list_final_en_0.pdf). Since 2008, non-steroidal selective androgen receptor modulators (SARMs) have been added to the list.

Anabolics are at the forefront of statistics on doping cases in competitive sports – 47% of positively tested samples in WADA laboratories in 2020. A serious phenomenon today is the spread of anabolics in recreational sports (bodybuilding, fitness), which is mainly mediated by online stores. Dosage regimens go far beyond those that would be appropriate for therapeutic use; drugs of dubious origin and composition are often used, including those that have already been ruled out by medicine for their side effects.


Oldřich Lapčík

CV: Narozen 1960 ve Zlíně, Česká republika. V roce 1989 absolvent magisterského studia (obor: biochemie) na Přírodovědecké fakultě University Karlovy v Praze (PřF UK Praha). V roce 1998 absolvent doktorského studia (obor: biochemie) na PřF UK Praha. Profesionální praxe: Endokrinologický ústav Praha (1989-2001), Vysoká škola chemicko- technologická (VŠCHT Praha; 2002-dosud) Od roku 2009 profesor na Ústavu chemie přírodních látek, Fakulta potravinářské a biochemické technologie, VŠCHT Praha. Výzkumné stáže v Německu, Finsku a Švédsku. Vedoucí řady bakalářských, magisterských a doktorských prací. Výzkum: Koordinátor nebo partner 8 národních projektů. Bibliografie: Autor nebo spoluautor 5 patentů, 2 kapitol v monografiích, 102 původních vědeckých článků a 80 odborně-popularizačních článků. Ostatní odborná činnost: Člen národních i mezinárodních vědeckých společností, člen vědeckých rad řady institucí, člen redakční rady odborně popularizačního časopisu Vesmír.

Oldřich Lapčík

CV: 1960 born in Zlín, Czech Republic. 1989 graduated in Biochemistry at Faculty of Science, Charles University Prague, Czech Republic. 1998 Doctorate in Biochemistry at Faculty of Science, Charles University Prague, Czech Republic. Working activities: Institute of Endocrinology Prague  (1989-2001), University of Chemistry and Technology Prague (UCT Prague; 2002-up to now). Since 2009, full professor at the Department of Chemistry of Natural Compounds, Faculty of Food and Biochemical Technology, UCT Prague. Several research stays in Germany, Finland, Sweden. Mentoring numerous bachelor, master and doctoral thesis. Research: Coordinator or partner in 8 national projects. Bibliography: Author or co-author of 5 patents, 2 chapters in monographs, 102 scientific papers, many contributions presented on international symposiums, 80 works popularizing science. Additionally: Member of several advisory boards, member of the editorial board of the science popularization journal Vesmír.

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